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When the researchers regarded at the cells that had tuberin “turned up”, they saw no changes in the cells when the identical hormones have been added. Kass says the analysis staff concluded that preserving tuberin “turned down” was like lifting the chemical foot off a brake pedal, triggering super-activity in …
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Mild-regulated protein-protein interactions can then be used to recruit proteins to DNA, for example to induce gene transcription or DNA modifications, or to the plasma membrane, for instance to activate resident signaling proteins. CRY2 also clusters when lively, so has been fused with signaling domains and subsequently photoactivated to permit …
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